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    Study on MRI changes in phenylketonuria in patients referred to mofid hospital/iran.

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    Author
    Parveneh Karimzadeh
    Farzad Ahmadabadi
    Narjes Jafari
    Fakhreddin Shariatmadari
    Hamid Nemati
    Adel Ahadi
    Sanaz Karimi Dardashti
    Mehrdad Mirzarahimi
    Zahra Dastborhan
    Javad Zare Noghabi
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    Abstract
    Phenylketonuria is one of the most common metabolic disorders and the first known cause of mental retardation in pediatrics. As Screening for phenylketonuria (PKU) is not a routine neurometabolic screening test for neonates in Iran, many PKU cases may be diagnosed after developing the clinical symptoms. One of the findings of PKU is myelination disorders, which is seen as hypersignal regions in T2-weighted (T2W) and FLAIR sequences of brain MRI. The aim of our study was to assess MRI changes in PKU patients referred to Mofid Children's Hospital, 2010-2011.
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