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    Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes

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    Date
    2017-03-16
    Author
    Ahmad Salimi
    Ahmad Salimi
    Ahmad Salimi
    Mehryar Habibi Roudkenar
    Enayatollah Seydi
    Leila Sadeghi
    Alireza Mohseni
    Nahal Pirahmadi
    Jalal Pourahmad
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    Abstract
    © 2017 Taylor & Francis Group, LLC. We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria. Our findings may provide a potential therapeutic approach for using chrysin to target mitochondria in CLL B-lymphocytes.
    DOI
    http://dx.doi.org/10.1080/07357907.2016.1276187
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