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dc.contributor.authorHajar Shali
dc.contributor.authorHajar Shali
dc.contributor.authorMahdi Shabani
dc.contributor.authorFatemeh Pourgholi
dc.contributor.authorMahsa Hajivalili
dc.contributor.authorLeili Aghebati-Maleki
dc.contributor.authorFarhad Jadidi-Niaragh
dc.contributor.authorBehzad Baradaran
dc.contributor.authorAli Akbar Movassaghpour Akbari
dc.contributor.authorVahid Younesi
dc.contributor.authorVahid Younesi
dc.contributor.authorMehdi Yousefi
dc.contributor.authorMehdi Yousefi
dc.date.accessioned2017-09-18T11:29:10Z
dc.date.available2017-09-18T11:29:10Z
dc.date.issued2017-03-30
dc.identifier.issn2169141X
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/72100
dc.description.abstract© 2017 Informa UK Limited, trading as Taylor & Francis Group Here, we investigated the effects of dual delivery of IGF-1R siRNA and doxorubicin by chitosan nanoparticles on viability of A549 lung cancer cells line by utilization of MTT and qRT-PCR. Furthermore apoptosis and migration of treated cells were assessed by Annexin-PI and wound healing assays, respectively. The chitosan nanoparticles had about 176 nm size with zeta potential and polydispersive index about 11 mV and 0.3, respectively. The IGF-1R siRNA had synergistic effect on DOX-induced cytotoxicity and apoptosis in tumour cells. In addition, siRNA/DOX-loaded chitosan nanoparticles could significantly decrease migration and expressions of mmp9, VEGF and STAT3 in A549 cells.
dc.sourceArtificial Cells, Nanomedicine and Biotechnology
dc.subjectChitosan nanoparticle
dc.subjectdoxorubicin
dc.subjectIGF-1R
dc.subjectlung cancer; ss siRNA
dc.titleCo-delivery of insulin-like growth factor 1 receptor specific siRNA and doxorubicin using chitosan-based nanoparticles enhanced anticancer efficacy in A549 lung cancer cell line
dc.identifier.doi10.1080/21691401.2017.1307212
dc.journal.pages1-10
dc.contributor.authorid57189694667
dc.contributor.authorid57189694667
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dc.contributor.citation57189694667|60031210|Hajar Shali
dc.contributor.citation57189694667|60031210|Hajar Shali
dc.contributor.citation56541072600|60018934|Mahdi Shabani
dc.contributor.citation55835724500|60031210|Fatemeh Pourgholi
dc.contributor.citation57063519900|60031210|Mahsa Hajivalili
dc.contributor.citation55622352500|60031210|Leili Aghebati-Maleki
dc.contributor.citation36024064100|60031210|Farhad Jadidi-Niaragh
dc.contributor.citation11640687900|60031210|Behzad Baradaran
dc.contributor.citation57188859784|60031210|Ali Akbar Movassaghpour Akbari
dc.contributor.citation35785397300|113774929|Vahid Younesi
dc.contributor.citation35785397300|113774929|Vahid Younesi
dc.contributor.citation16235087000|60031210|Mehdi Yousefi
dc.contributor.citation16235087000|60031210|Mehdi Yousefi
dc.contributor.affiliationid60031210
dc.contributor.affiliationid60031210
dc.contributor.affiliationid60018934
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dc.contributor.affiliationid60031210
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dc.contributor.affiliationid113774929
dc.contributor.affiliationid113774929
dc.contributor.affiliationid60031210
dc.contributor.affiliationid60031210


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