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    Co-delivery of insulin-like growth factor 1 receptor specific siRNA and doxorubicin using chitosan-based nanoparticles enhanced anticancer efficacy in A549 lung cancer cell line

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    Date
    2017-03-30
    Author
    Hajar Shali
    Hajar Shali
    Mahdi Shabani
    Fatemeh Pourgholi
    Mahsa Hajivalili
    Leili Aghebati-Maleki
    Farhad Jadidi-Niaragh
    Behzad Baradaran
    Ali Akbar Movassaghpour Akbari
    Vahid Younesi
    Vahid Younesi
    Mehdi Yousefi
    Mehdi Yousefi
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    Abstract
    © 2017 Informa UK Limited, trading as Taylor & Francis Group Here, we investigated the effects of dual delivery of IGF-1R siRNA and doxorubicin by chitosan nanoparticles on viability of A549 lung cancer cells line by utilization of MTT and qRT-PCR. Furthermore apoptosis and migration of treated cells were assessed by Annexin-PI and wound healing assays, respectively. The chitosan nanoparticles had about 176 nm size with zeta potential and polydispersive index about 11 mV and 0.3, respectively. The IGF-1R siRNA had synergistic effect on DOX-induced cytotoxicity and apoptosis in tumour cells. In addition, siRNA/DOX-loaded chitosan nanoparticles could significantly decrease migration and expressions of mmp9, VEGF and STAT3 in A549 cells.
    DOI
    http://dx.doi.org/10.1080/21691401.2017.1307212
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