• Login
    View Item 
    •   DSpace Home
    • School of Medicine
    • Journal Papers in Scopus 2
    • View Item
    •   DSpace Home
    • School of Medicine
    • Journal Papers in Scopus 2
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    A computational model to investigate astrocyte glutamate modulation effect on tripartite synapse and neuronal network state

    Thumbnail
    Date
    2017-03-30
    Author
    Mohammad Mohammadi
    Fariba Bahrami
    Mahyar Janahmadi
    Metadata
    Show full item record
    Abstract
    © 2016 IEEE. Astrocytes, most numerous glial cells in brain, respond to neural activities by provoking calcium waves and releasing transmitters to adjacent synapses and consequently, modulate neural activities. Here, we used leaky integrate and fire (LIF) neuron and a minimal functional astrocyte models with detailed synaptic mechanism to investigate astrocyte modulation impact on firing of tripartite synapse and network firing states. We assumed astrocyte facilitates and depress synapses by D-serine acting on N-methyl-d-Aspartic acid (NMDA) receptors in post-synaptic neuron, and glutamate acting on metabotropic glutamate receptors (mGluRs) in pre-synaptic terminal. The model predicted that in the presence of astrocyte, a tripartite synapse exhibited bi-stable activity in the terms of pre-And post-synaptic neural firing rate; and neural population with bi-stable characteristic exhibited more stability on high firing rates, and impaired astrocyte function lead to less stable network activity.
    DOI
    http://dx.doi.org/10.1109/ICBME.2016.7890956
    Collections
    • Journal Papers in Scopus 2

    Contact Us | Send Feedback
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Contact Us | Send Feedback