Risk of coronary heart events based on rose angina questionnaire and ECG besides diabetes and other metabolic risk factors: Results of a 10-year follow-up in Tehran lipid and glucose study

Abstract

© 2017, Research Institute For Endocrine Sciences and Iran Endocrine Society. Background: High-risk individuals forCHDcould be diagnosed bysomenon-invasive and low-priced techniques such as Minnesota ECG coding and rose angina questionnaire (RQ). Objectives: The present study aimed at determining the risk of incident CHD according to ECG and RQ besides diabetes and other metabolic risk factors in our population. Methods: Participants comprised of 5431 individuals aged ≥ 30 years within the framework of Tehran lipidandglucose study. Based on their status on history of CHD, ECG, andRQat baseline, all participants were classified to 5 following groups: (1) History - Rose-ECG - (the reference group); (2) History - Rose + ECG - ; (3) History - Rose-ECG + ; (4) History - Rose + ECG + ; and (5) History + . We used Cox regression model to find the role of ECG and RQ on CHD, independent of other risk factors. Results: Overall, 562 CHD events were detected during the median of 10.3 years follow-up. CHD incidence rates were 55.9 and 9.09 cases per 1000 person-year for participants with and without history of CHD, respectively. Hazard ratios (HRs) (95% CIs) were 4.11 (3.27 - 5.11) for History + and 2.18 (1.63 - 2.90), 1.92 (1.47 - 2.51), and 2.48 (1.46 - 4.20) for History - Rose + ECG - , History - Rose-ECG + , and History - Rose + ECG + , respectively. RQ and ECG had the same HRs as high as those for hypertension and hypercholesterolemia; however, diabetes showed statistically and clinically more effects on CVD than RQ and ECG. Conclusions: RQ in general and, ECG especially in asymptomatic patients, were good predictors for CHD events in both Iranian males and females; however, their predictive powers were lower than that of diabetes.