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dc.contributor.authorM. Eskandari
dc.contributor.authorA. Ghalyanchi Langeroudi
dc.contributor.authorH. Zeighami
dc.contributor.authorA. Rostami
dc.contributor.authorM. Kazemi
dc.contributor.authorH. Eyni
dc.contributor.authorS. Shokri
dc.date.accessioned2017-09-18T11:28:55Z
dc.date.available2017-09-18T11:28:55Z
dc.date.issued2017-04-01
dc.identifier.issn14390272
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/72056
dc.description.abstract© 2016 Blackwell Verlag GmbH Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo-orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham-operated (SH), EO (E); ciprofloxacin (C), EO–ciprofloxacin (EC), KRG (G), EO–KRG (EG), ciprofloxacin–KRG (CG) and EO–ciprofloxacin–KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG a nd ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co-administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.
dc.sourceAndrologia
dc.subjectapoptosis
dc.subjectciprofloxacin
dc.subjectepididymo-orchitis
dc.subjectginseng
dc.titleCo-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats
dc.journal.volume49
dc.journal.issue3
dc.identifier.doi10.1111/and.12621
dc.journal.pages
dc.contributor.authorid12140467800
dc.contributor.authorid54994186700
dc.contributor.authorid23037797100
dc.contributor.authorid57189855220
dc.contributor.authorid56529113500
dc.contributor.authorid57189515993
dc.contributor.authorid8856710600
dc.contributor.citation12140467800|60012874|M. Eskandari
dc.contributor.citation54994186700|60012874|A. Ghalyanchi Langeroudi
dc.contributor.citation23037797100|60012874|H. Zeighami
dc.contributor.citation57189855220|60012874|A. Rostami
dc.contributor.citation56529113500|60018934|M. Kazemi
dc.contributor.citation57189515993|60032053|H. Eyni
dc.contributor.citation8856710600|60012874|S. Shokri
dc.contributor.affiliationid60012874
dc.contributor.affiliationid60012874
dc.contributor.affiliationid60012874
dc.contributor.affiliationid60012874
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60032053
dc.contributor.affiliationid60012874


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