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dc.contributor.authorMakan Sadr
dc.contributor.authorMakan Sadr
dc.contributor.authorSeyed Mohammad Hossein Noori Mugahi
dc.contributor.authorGholamreza Hassanzadeh
dc.contributor.authorSeyed Alireza Nadji
dc.contributor.authorArda Kiani
dc.contributor.authorAtefeh Abedini
dc.contributor.authorAlireza Javadi
dc.contributor.authorForozan Mohammadi
dc.contributor.authorMohammad Reza Masjedi
dc.contributor.authorMoslem Bahadori
dc.date.accessioned2017-09-18T10:50:40Z
dc.date.available2017-09-18T10:50:40Z
dc.date.issued2015-01-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/67399
dc.description.abstract© 2015 NRITLD. Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not completely reversible by administration of inhaled bronchodilators. Many studies propose that telomere length shortening might have occurred in COPD patients. We aimed to determine the telomere length in COPD patients and compare the results of non-smoking and smoking control subjects. Materials and Methods: In our case-control study, 84 clinically stable COPD patients were recruited on admission to Masih Daneshvari Hospital. Eighty-five healthy controls were also selected including 45 non-smokers and 40 smokers admitted for diseases other than COPD. Spirometry was done for all subjects. Telomere length was measured by quantitative real time PCR as described by Cawthon. The telomere repeat copy number (T) to single-gene cop y number(S) ratio was calculated using the comparative C < inf > t < /inf > method. Results: The mean ±SD of age was 64.33±10.04 years in patients and 65.06 ±10.02 years in controls (P=0.693). The mean ±SD of FEV1 was 1.62±0.75 L in patients, 2.84±0.54 L in smoker controls and 2.83±0.56 L in non-smoker controls; significant differences were detected in this regard between cases and controls (P < 0.001). T/S ratio was significantly lower in COPD patients (0.61±0.08) than in the control subjects (0.69±0.09) (P < 0.001). However, telomere length was shorter in the patients than in controls in each age group (P < 0.001). Additionally, there were no statistically significant differences in telomere length between the smoker and non-smoker control subjects. Regarding the correlation between BMI and telomere length, there were no significant differences among the patients and control groups. Conclusion: In conclusion, we found that telomere length in COPD patients was shorter than that in smoker and non-smoker controls, irrespective of age, sex, spirometric variables, BMI and history of cigarette smoking.
dc.sourceTanaffos
dc.subjectAging
dc.subjectChronic obstructive pulmonary disease
dc.subjectTelomere
dc.subjectTelomere length
dc.titleTelomere shortening in blood leukocytes of patients with chronic obstructive pulmonary disease
dc.journal.volume14
dc.journal.issue1
dc.journal.pages10-16
dc.contributor.authorid29567551700
dc.contributor.authorid29567551700
dc.contributor.authorid14037948300
dc.contributor.authorid6508180090
dc.contributor.authorid56626452300
dc.contributor.authorid23969224700
dc.contributor.authorid56082100300
dc.contributor.authorid56556231200
dc.contributor.authorid35618870900
dc.contributor.authorid6603406130
dc.contributor.authorid57190515980
dc.contributor.citation29567551700|60027708|Makan Sadr
dc.contributor.citation29567551700|60027708|Makan Sadr
dc.contributor.citation14037948300|60027708|Seyed Mohammad Hossein Noori Mugahi
dc.contributor.citation6508180090|60027708|Gholamreza Hassanzadeh
dc.contributor.citation56626452300|60011822|Seyed Alireza Nadji
dc.contributor.citation23969224700|60011822|Arda Kiani
dc.contributor.citation56082100300|60011822|Atefeh Abedini
dc.contributor.citation56556231200|60011822|Alireza Javadi
dc.contributor.citation35618870900|60011822|Forozan Mohammadi
dc.contributor.citation6603406130|60011822|Mohammad Reza Masjedi
dc.contributor.citation57190515980|60011822|Moslem Bahadori
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822
dc.contributor.affiliationid60011822


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