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dc.contributor.authorRoberto Catanzaro
dc.contributor.authorRoberto Catanzaro
dc.contributor.authorGulcin Celep
dc.contributor.authorNicola Zerbinati
dc.contributor.authorMichael Papacharalambous
dc.contributor.authorRavinder Nagpal
dc.contributor.authorFrancesco Marotta
dc.contributor.authorReza Rastamanesh
dc.contributor.authorMichele Milazzo
dc.contributor.authorAldo Lorenzetti
dc.contributor.authorG. Bertuccelli
dc.contributor.authorJ. Sollano
dc.date.accessioned2017-09-18T10:47:38Z
dc.date.available2017-09-18T10:47:38Z
dc.date.issued2014-01-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/66909
dc.description.abstractThe purpose of this study was to assess the effect of Celergen, a marine nutraceutical, against tumor cell invasion in human pancreatic cancer cell line (PSN-I).High invasive clone (HI) and low invasive clone (LI) were established from wild type PSN-l cell line after a repeated invasion assay test.The invasive ability of HI cells and the level of IL-6 in the conditioned medium of HI cells was significantly higher than that one of LI cells but both these parameters were significantly reduced by the addition of Celergen (p < 0.01). Exogenous IL-6 administration induced a dose dependent enhancement of invasive ability in both cell populations.Moreover, IL-6 receptor expression was detected in 72 % of HI cells whereas this occurred only in 37 % of LI cells.When co-cultured with Celergen this parameter was significantly downregulated in both cellular subsets (p < 0.05).The addition of conditioned medium derived fromHI cells (HCM) and LI cells (LCM) enhanced the invasive ability in both cell populations without affecting cell proliferation.The effect ofHCMon the invasive ability ofHI cells was partially inhibited by the addition of Celergen (p < 0.01). In summary, overexpression of IL-6 and its receptor may be one relevant factor contributing to the highly invasive characteristic of the pancreatic cancer cell line we used while a significantly beneficial modulation was obtained by applying this novel marine nutraceutical.This advices to further explore the possibility of marine compounds regulation of IL-6 ligand/receptor and other possible invasive factor interaction in the therapy of this malignancy while further studies are awaited in this setting. © Mattioli 1885.
dc.sourceActa Biomedica
dc.subjectCelergen
dc.subjectInteleukin-6 receptor
dc.subjectInterleukin-6
dc.subjectInvasiveness
dc.subjectMarine compound
dc.subjectPancreatic cancer
dc.titleIn vitro protective effect of Celergen, a bioactive marine compound, on interleukin-6-related invasiveness of pancreatic cancer
dc.journal.volume85
dc.journal.issue1
dc.journal.pages44-51
dc.contributor.authorid6603833058
dc.contributor.authorid6603833058
dc.contributor.authorid55840400200
dc.contributor.authorid6602265280
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dc.contributor.authorid35550520900
dc.contributor.authorid56181517600
dc.contributor.authorid55840576100
dc.contributor.authorid24167020200
dc.contributor.authorid56159415300
dc.contributor.authorid6602099153
dc.contributor.citation6603833058|60010146|Roberto Catanzaro
dc.contributor.citation6603833058|60010146|Roberto Catanzaro
dc.contributor.citation55840400200|60013849|Gulcin Celep
dc.contributor.citation6602265280|113843398|Nicola Zerbinati
dc.contributor.citation56181338300|60019548|Michael Papacharalambous
dc.contributor.citation23393366000|60032116|Ravinder Nagpal
dc.contributor.citation35550520900|112795295|Francesco Marotta
dc.contributor.citation56181517600|60018934|Reza Rastamanesh
dc.contributor.citation55840576100|60010146|Michele Milazzo
dc.contributor.citation24167020200|112795295|Aldo Lorenzetti
dc.contributor.citation56159415300|112795295|G. Bertuccelli
dc.contributor.citation6602099153|60071488|J. Sollano
dc.contributor.affiliationid60010146
dc.contributor.affiliationid60010146
dc.contributor.affiliationid60013849
dc.contributor.affiliationid113843398
dc.contributor.affiliationid60019548
dc.contributor.affiliationid60032116
dc.contributor.affiliationid112795295
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60010146
dc.contributor.affiliationid112795295
dc.contributor.affiliationid112795295
dc.contributor.affiliationid60071488


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