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dc.contributor.authorZahra Saadatian
dc.contributor.authorAndrea Masotti
dc.contributor.authorZiba Nariman Saleh Fam
dc.contributor.authorBehnam Alipoor
dc.contributor.authorMilad Bastami
dc.contributor.authorMilad Bastami
dc.contributor.authorHamid Ghaedi
dc.date.accessioned2017-09-18T10:47:37Z
dc.date.available2017-09-18T10:47:37Z
dc.date.issued2014-01-01
dc.identifier.issn20741812
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/66906
dc.description.abstractBackground: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to GIT cancers. Accordingly, recent works have shown that single-nucleotide polymorphisms (SNPs) within miRNAs coding sequence (miR-SNPs) and miRNA target sites (target-SNPs) may further contribute to increased risk of developing cancer. Objectives: In this study, we comprehensively identified miRNA-target gene pairs implicated in GIT cancers and catalogued the presence of potentially functional miR-SNPs and target-SNPs that impair the correct functional recognition. Materials and Methods: Using bioinformatics tools, manual literature review, and a highly accurate dataset of experimentally validated miRNA-target gene interactions, we compiled a list of miRNA-target genes pairs related to GIT cancers and prioritized them into different groups based on the levels of experimental support. Functional annotations (gene ontology) were applied to these pairs in each group to gain further information. Results: We identified 97 pairs in which both miRNAs and target genes were implicated in GIT cancers. Several pairs, denoted as highly polymorphic pairs, had both miR-SNPs and target-SNPs. In addition, more than 5000 miRNA-target gene pairs were identified in which, according to the previous reports, either the miRNAs or the target genes had a direct involvement in GIT cancers. More than 800 target-SNPs are located in regulatory regions that were extracted from the ENCODE project through the RegulomeDB database. Of these, 20 were classified as expression quantitative trait loci (eQTLs). Conclusions: Our work provided a comprehensive source of prioritized and annotated candidate polymorphisms inside miRNAs and their target sites in GIT cancers, which would facilitate the process of choosing right candidate miRNA-target genes and related polymorphisms for future association or functional studies. © 2014, Iranian Red Crescent Medical Journal.
dc.sourceIranian Red Crescent Medical Journal
dc.subjectColorectal neoplasms
dc.subjectEsophageal neoplasms
dc.subjectGastric neoplasms
dc.subjectGastrointestinal neoplasms
dc.subjectMicroRNAs
dc.subjectSingle nucleotide polymorphisms
dc.titleSingle-nucleotide polymorphisms within microRNAs sequences and their 3' UTR target sites may regulate gene expression in gastrointestinal tract cancers
dc.journal.volume16
dc.journal.issue7
dc.identifier.doi10.5812/ircmj.16659
dc.journal.pages
dc.contributor.authorid56303466100
dc.contributor.authorid35242801000
dc.contributor.authorid54790044800
dc.contributor.authorid54683478100
dc.contributor.authorid55643811800
dc.contributor.authorid55643811800
dc.contributor.authorid56303242500
dc.contributor.citation56303466100|60031210|Zahra Saadatian
dc.contributor.citation35242801000|60017905|Andrea Masotti
dc.contributor.citation54790044800|60027708|Ziba Nariman Saleh Fam
dc.contributor.citation54683478100|60027708|Behnam Alipoor
dc.contributor.citation55643811800|60018934|Milad Bastami
dc.contributor.citation55643811800|60018934|Milad Bastami
dc.contributor.citation56303242500|60018934|Hamid Ghaedi
dc.contributor.affiliationid60031210
dc.contributor.affiliationid60017905
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934


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