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dc.contributor.authorJ. Jamshidi
dc.contributor.authorA. Movafagh
dc.contributor.authorA. Movafagh
dc.contributor.authorB. Emamalizadeh
dc.contributor.authorA. Zare Bidoki
dc.contributor.authorA. Zare Bidoki
dc.contributor.authorA. Manafi
dc.contributor.authorS. Ghasemi Firouzabadi
dc.contributor.authorG. A. Shahidi
dc.contributor.authorS. Kazeminasab
dc.contributor.authorP. Petramfar
dc.contributor.authorA. Fazeli
dc.contributor.authorM. Motallebi
dc.contributor.authorS. A. Mortazavi-Tabatabaei
dc.contributor.authorA. Kowsari
dc.contributor.authorZ. Jafarian
dc.contributor.authorH. Darvish
dc.date.accessioned2017-09-18T10:47:28Z
dc.date.available2017-09-18T10:47:28Z
dc.date.issued2014-01-01
dc.identifier.issn1744313X
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/66882
dc.description.abstract© 2014 John Wiley & Sons Ltd. The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls (χ < sup > 2 < /sup > = 4.64, P = 0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data.
dc.sourceInternational Journal of Immunogenetics
dc.titleHLA-DRA is associated with Parkinson's disease in Iranian population
dc.journal.volume41
dc.journal.issue6
dc.identifier.doi10.1111/iji.12151
dc.journal.pages508-511
dc.contributor.authorid55667802600
dc.contributor.authorid16402418400
dc.contributor.authorid16402418400
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dc.contributor.citation55667802600|60022657|J. Jamshidi
dc.contributor.citation16402418400|60018934|A. Movafagh
dc.contributor.citation16402418400|60018934|A. Movafagh
dc.contributor.citation55645580600|60018934|B. Emamalizadeh
dc.contributor.citation56323355200|60027708|A. Zare Bidoki
dc.contributor.citation56323355200|60027708|A. Zare Bidoki
dc.contributor.citation56418303300|60022657|A. Manafi
dc.contributor.citation36571628600|60072432|S. Ghasemi Firouzabadi
dc.contributor.citation24330211500|60024852|G. A. Shahidi
dc.contributor.citation55207269000|60072432|S. Kazeminasab
dc.contributor.citation26634239300|60021948|P. Petramfar
dc.contributor.citation56320205300|60018934|A. Fazeli
dc.contributor.citation56320306000|60018934|M. Motallebi
dc.contributor.citation55392666500|60018934|S. A. Mortazavi-Tabatabaei
dc.contributor.citation35290737900|60016689|A. Kowsari
dc.contributor.citation56418422500|60072432|Z. Jafarian
dc.contributor.citation23469377300|60018934|H. Darvish
dc.contributor.affiliationid60022657
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dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60027708
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dc.contributor.affiliationid60018934
dc.contributor.affiliationid60016689
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dc.contributor.affiliationid60018934


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