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dc.contributor.authorSamira Gilanchi
dc.contributor.authorSamira Gilanchi
dc.contributor.authorBanafshe Esmaeilzade
dc.contributor.authorBanafshe Esmaeilzade
dc.contributor.authorAkram Eidi
dc.contributor.authorMahmood Barati
dc.contributor.authorSoraya Mehrabi
dc.contributor.authorFatima Moghani Ghoroghi
dc.contributor.authorMaliheh Nobakht
dc.contributor.authorMaliheh Nobakht
dc.contributor.authorMaliheh Nobakht
dc.date.accessioned2017-09-18T10:47:19Z
dc.date.available2017-09-18T10:47:19Z
dc.date.issued2014-01-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/66850
dc.description.abstractBackground: The seladin-1 (selective Alzheimer disease indicator-1), also known as DHCR24, is a gene found to be down-regulated in brain region affected by Alzheimer disease (AD). Whereas, hair follicle stem cells (HFSC), which are affected in with neurogenic p otential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. Our aim was to evaluate seladin-1 gene expression in hair follicle stem cells. Methods: In this study, bulge area of male Wistar rat HFSC were cultured and then characterized with Seladin-1 immunocytochemistry and flow cytometry on days 8 to 14. Next, 9-11-day cells were evaluated for seladin-1 gene expression by real-time PCR. Results: Our results indicated that expression of the seladin-1 gene (DHCR24) on days 9, 10, and 11 may contribute to the development of HFSC. However, the expression of this gene on day 11 was more than day 10 and on 10 th day was more than day 9. Also, we assessed HFSC on day 14 and demonstrated these cells were positive for β-III tubulin, and seladin-1 was not expressed in this day. Conclusion: HFSC express seladin-1 and this result demonstrates that these cells might be used to cell therapy for AD in future.
dc.sourceIranian Biomedical Journal
dc.subjectAlzheimer disease (AD)
dc.subjectHair follicle stem cells
dc.subjectSeladin-1 (selective Alzheimer disease indicator-1)
dc.titleNeuronal differentiation of rat hair follicle stem cells: The involvement of the neuroprotective factor seladin-1 (DHCR24)
dc.journal.volume18
dc.journal.issue3
dc.identifier.doi10.6091/ibj.1284.2014
dc.journal.pages136-142
dc.contributor.authorid55945402200
dc.contributor.authorid55945402200
dc.contributor.authorid55361397700
dc.contributor.authorid55361397700
dc.contributor.authorid6507379422
dc.contributor.authorid56288933200
dc.contributor.authorid44861359200
dc.contributor.authorid55542974400
dc.contributor.authorid15520129900
dc.contributor.authorid15520129900
dc.contributor.authorid15520129900
dc.contributor.citation55945402200|107573391|Samira Gilanchi
dc.contributor.citation55945402200|107573391|Samira Gilanchi
dc.contributor.citation55361397700|107573391|Banafshe Esmaeilzade
dc.contributor.citation55361397700|107573391|Banafshe Esmaeilzade
dc.contributor.citation6507379422|60031777|Akram Eidi
dc.contributor.citation56288933200|60018934|Mahmood Barati
dc.contributor.citation44861359200|60022927|Soraya Mehrabi
dc.contributor.citation55542974400|60024852|Fatima Moghani Ghoroghi
dc.contributor.citation15520129900|107573391|Maliheh Nobakht
dc.contributor.citation15520129900|107573391|Maliheh Nobakht
dc.contributor.citation15520129900|107573391|Maliheh Nobakht
dc.contributor.affiliationid107573391
dc.contributor.affiliationid107573391
dc.contributor.affiliationid107573391
dc.contributor.affiliationid107573391
dc.contributor.affiliationid60031777
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60022927
dc.contributor.affiliationid60024852
dc.contributor.affiliationid107573391
dc.contributor.affiliationid107573391
dc.contributor.affiliationid107573391


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