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dc.contributor.authorTouraj Mahmoudi
dc.contributor.authorKhatoon Karimi
dc.contributor.authorMaral Arkani
dc.contributor.authorHamid Farahani
dc.contributor.authorMohsen Vahedi
dc.contributor.authorReza Dabiri
dc.contributor.authorHossein Nobakht
dc.contributor.authorAsadollah Asadi
dc.contributor.authorMojgan Mirakhorli
dc.contributor.authorBenafsheh Arshi
dc.contributor.authorArash Derakhshan
dc.contributor.authorMohammad Reza Zali
dc.date.accessioned2017-09-18T10:46:43Z
dc.date.available2017-09-18T10:46:43Z
dc.date.issued2014-01-01
dc.identifier.issn17246008
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/66763
dc.description.abstract© 2014 Wichtig Publishing. Materials and methods: All 414 subjects, including 197 cases with CRC and 217 controls, were genotyped for the GHRL (rs26802) and RETN (rs1862513) or-420C > G gene variants using the PCR-RFLP method. Results: Our findings indicated that the RETN -420C > G “CC” genotype, compared with the “GG” and “GC” genotypes, was a marker of decreased CRC susceptibility; the difference remained significant after adjustment for age, BMI, gender, smoking status, NSAID use, and family history of CRC (p=0.020; OR=0.52, 95% CI=0.30-0.90). Furthermore, after adjustment for confounding factors, the -420C > G “CC” genotype, compared with the “GG” genotype, was associated with a decreased risk for CRC (p=0.044; OR=0.53, 95% CI=0.29-0.98). In addition, no significant difference was observed for the GHRL (rs26802) gene variant. Conclusions: To our knowledge, this is the first study suggesting that the RETN -420C > G “CC” genotype is a marker of decreased CRC susceptibility. This observation is relevant from a scientific perspective and deserves further investigations. Purposes: Obesity is associated with an increased risk of colorectal cancer (CRC), and ghrelin (GHRL) and resistin (RETN) are thought to be related to obesity. Our aim was to investigate whether GHRL and RETN gene variants are associated with CRC risk.
dc.sourceInternational Journal of Biological Markers
dc.subjectColorectal cancer
dc.subjectGhrelin
dc.subjectObesity
dc.subjectResistin
dc.subjectVariant
dc.titleResistin -420C>G promoter variant and colorectal cancer risk
dc.journal.volume29
dc.journal.issue3
dc.identifier.doi10.5301/jbm.5000079
dc.journal.pagese233-e238
dc.contributor.authorid26030018500
dc.contributor.authorid49863619500
dc.contributor.authorid53866148000
dc.contributor.authorid36536730400
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dc.contributor.authorid8590469700
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dc.contributor.authorid56708684200
dc.contributor.authorid56049344200
dc.contributor.authorid6602567324
dc.contributor.citation26030018500|60018934|Touraj Mahmoudi
dc.contributor.citation49863619500|60018934|Khatoon Karimi
dc.contributor.citation53866148000|60018934|Maral Arkani
dc.contributor.citation36536730400|60088054|Hamid Farahani
dc.contributor.citation26636085000|60027708|Mohsen Vahedi
dc.contributor.citation55479351500|60024530|Reza Dabiri
dc.contributor.citation8590469700|60024530|Hossein Nobakht
dc.contributor.citation25722899800|60022605|Asadollah Asadi
dc.contributor.citation55356613300|60022605|Mojgan Mirakhorli
dc.contributor.citation56708684200|60018934|Benafsheh Arshi
dc.contributor.citation56049344200|60018934|Arash Derakhshan
dc.contributor.citation6602567324|60018934|Mohammad Reza Zali
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60088054
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60024530
dc.contributor.affiliationid60024530
dc.contributor.affiliationid60022605
dc.contributor.affiliationid60022605
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934


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