Prognostic value of transforming growth factor beta 1 [TGF-β1] and matrix metalloproteinase 9 [MMP-9] in oral squamous cell carcinoma
Nasim Taghavi Ghasemian
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Objectives: The prognostic value of MMP-9 and TGF-β1 in oral squamous cell carcinoma (OSCC) is not clear. This study aimed to assess this subject. Methods: After immunohistochemistry staining of 48 OSCC biopsies with MMP-9 and TGF-β1 markers, marker expression in the stroma was estimated, and the correlations with OSCC prognosis determinants were analyzed (α=0.05). Results: Mode of invasion was associated with metastasis (rho=0.449, p=0.008). MMP-9 was positively associated with metastasis and mode of invasion. TGF-β1 was negatively correlated to tumor histologic grade but was positively associated with metastasis. Conclusions: Unlike TGF-β1, MMP-9 might be useful for prognosis determination. © 2012 Informa UK, Ltd.