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dc.contributor.authorJalal Pourahmad
dc.contributor.authorMohammad Reza Eskandari
dc.contributor.authorGolbarg Alavian
dc.contributor.authorFatemeh Shaki
dc.date.accessioned2017-09-18T10:03:25Z
dc.date.available2017-09-18T10:03:25Z
dc.date.issued2012-02-01
dc.identifier.issn10290486
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/61592
dc.description.abstractMethyl tertiary butyl ether (MTBE) is the most widely used motor vehicle fuel oxygenate since it reduces automobile emissions of carbon monoxide and compounds involved in photochemical smog formation. The increasing use of MTBE raised concern over its health safety. The cytotoxic mechanism of MTBE was investigated in freshly isolated rat hepatocytes. MTBE cytotoxicity was associated with reactive oxygen species (ROS) formation and glutathione (GSH) depletion suggesting that oxidative stress contributes to the MTBE cytotoxic mechanism. In this study the hepatocyte mitochondrial membrane potential was rapidly decreased by MTBE which was prevented by antioxidants and ROS scavenger, suggesting that mitochondrial membrane damage was a consequence of ROS formation. MTBE cytotoxicity was also associated with lysosomal membrane leakiness. Data showed that in the addition to CYP2E1, GSH is also involved in metabolic activation of MTBE. MTBE-mediated oxidative stress cytotoxicity and subsequent methylation is the unique pathway for detoxification. © 2012 Copyright Taylor and Francis Group, LLC.
dc.sourceToxicological and Environmental Chemistry
dc.subjectglutathione
dc.subjectlysosomes
dc.subjectmethyl tertiary butyl ether
dc.subjectmethylation
dc.subjectmitochondria
dc.subjectoxidative stress
dc.titleLysosomal membrane leakiness and metabolic biomethylation play key roles in methyl tertiary butyl ether-induced toxicity and detoxification
dc.journal.volume94
dc.journal.issue2
dc.identifier.doi10.1080/02772248.2011.643566
dc.journal.pages281-293
dc.contributor.authorid6603568950
dc.contributor.authorid35487437900
dc.contributor.authorid55220117700
dc.contributor.authorid21740207700
dc.contributor.citation6603568950|60018934|Jalal Pourahmad
dc.contributor.citation35487437900|60012874|Mohammad Reza Eskandari
dc.contributor.citation55220117700|60018934|Golbarg Alavian
dc.contributor.citation21740207700|60018934|Fatemeh Shaki
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60012874
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934


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