EVects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: A double blind randomized clinical trial
Mohammad Mohsen Mazloomfard
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Purpose Gabapentin has demonstrated analgesic eVects in some studies. This double blind randomized clinical trial (RCT) was conducted to evaluate whether the pre-emptive use of gabapentin 600 mg could reduce postoperative pain, nausea and vomiting, and meperidine consumption in patients after hysterectomy. Methods Between 2009 and 2010, a total of 170 patients who were candidates for abdominal hysterectomy were assessed for eligibility to enter the study. Thirty patients were excluded for diVerent reasons; and 140 included patients were randomly assigned to one of two groups according to the method of treatment, gabapentin or placebo, in a double-blind manner before hysterectomy. Postoperatively, the pain was assessed on a visual analogue scale (VAS) at 1, 4, 8, 12 and 24 h at rest. Meperidine intramuscularly was used to treat postoperative pain on VAS score and patients demand. Total meperidine and anti emetic drug consumption in the Wrst 24 h after surgery was also recorded. The trial is registered at irct.ir, number IRCT201106186829N1. Results Patients in the gabapentin group had signiWcantly lower VAS scores at all time intervals, than those in the placebo group. The total meperidine consumed in the gabapentin group was signiWcantly less than in the placebo group. Postoperative nausea and vomiting (PONV) and anti emetic drug consumption were signiWcantly decreased in gabapentin group. Conclusion Pre-emptive use of gabapentin 600 mg orally, signiWcantly decreases postoperative pain and PONV, and also rescues analgesic and anti emetic drug requirements in patients who undergo abdominal hysterectomy. © Springer-Verlag 2011.