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dc.contributor.authorRamin Hajikhani
dc.contributor.authorAbbas Ahmadi
dc.contributor.authorNima Naderi
dc.contributor.authorKayvan Yaghoobi
dc.contributor.authorZahra Shirazizand
dc.contributor.authorNazereh M. Rezaee
dc.contributor.authorBabak N. Niknafs
dc.date.accessioned2017-09-18T10:01:10Z
dc.date.available2017-09-18T10:01:10Z
dc.date.issued2012-05-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/61319
dc.description.abstractObjectives. The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test. Material and Methods. Phencyclidine and its derivatives (M, F, L, B, S, P) were administrated intraperitoneally (i.p.) at a dose of 10 mg/kg to male mice. Anxiety-like behaviors were assessed using the elevated-plus maze test. Results. EPM results revealed an increase in open arms time spent after applying PCP and M, L, P, and B compounds at the administered dosage. Moreover, an increase in the number of open arm entries was observed with M, P, and B compounds. The P, B and S compounds increased the locomotion of animals, too, which might be considered as the side effect to the compounds. Conclusions. Considering the elevated-plus maze results, it was concluded that M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds. © Copyright by Wroclaw Medical University.
dc.sourceAdvances in Clinical and Experimental Medicine
dc.subjectAnxiety-like behavior
dc.subjectElevated-plus maze test
dc.subjectMice
dc.subjectPhencyclidine derivatives
dc.titleEffect of phencyclidine derivatives on anxiety-like behavior using an elevated-plus maze test in mice
dc.journal.volume21
dc.journal.issue3
dc.journal.pages307-312
dc.contributor.authorid35068024200
dc.contributor.authorid56429961300
dc.contributor.authorid23088871800
dc.contributor.authorid55312223800
dc.contributor.authorid55312224300
dc.contributor.authorid55311803200
dc.contributor.authorid55047948200
dc.contributor.citation35068024200|60103927|Ramin Hajikhani
dc.contributor.citation56429961300|60103927|Abbas Ahmadi
dc.contributor.citation23088871800|60018934|Nima Naderi
dc.contributor.citation55312223800|60018934|Kayvan Yaghoobi
dc.contributor.citation55312224300|60018934|Zahra Shirazizand
dc.contributor.citation55311803200|60103927|Nazereh M. Rezaee
dc.contributor.citation55047948200|60103927|Babak N. Niknafs
dc.contributor.affiliationid60103927
dc.contributor.affiliationid60103927
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60103927
dc.contributor.affiliationid60103927


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