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dc.contributor.authorMohieddin Jafari
dc.contributor.authorMehdi Sadeghi
dc.contributor.authorMehdi Mirzaie
dc.contributor.authorMehdi Mirzaie
dc.contributor.authorSayed Amir Marashi
dc.contributor.authorMostafa Rezaei-Tavirani
dc.date.accessioned2017-09-18T10:00:37Z
dc.date.available2017-09-18T10:00:37Z
dc.date.issued2013-11-01
dc.identifier.issn18728278
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/61234
dc.description.abstractAdvances in organelle interactomics have led to new insights into organelle functions. In this study, we considered the common mitochondrial PIN of four evolutionarily distant eukaryotic species, namely Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans. By comparative interactomics analysis of mitochondrial PINs in these organisms, five conserved modules were identified. Modules comprise the main mitochondrial tasks, including proteins involved in translation process, mitochondrial import inner membrane proteins, TCA cycle enzymes, mitochondrial electron transport chain, and metabolic enzymes. Furthermore, we reemphasize that subgraphs of network, i.e., motifs and themes, may represent evolutionarily conserved topological units which are biologically significant. © 2013 Elsevier B.V.
dc.sourceMitochondrion
dc.subjectComparative interactomics
dc.subjectEvolution
dc.subjectMitochondria
dc.subjectOrganelle interactomics
dc.titleEvolutionarily conserved motifs and modules in mitochondrial protein-protein interaction networks
dc.journal.volume13
dc.journal.issue6
dc.identifier.doi10.1016/j.mito.2013.09.006
dc.journal.pages668-675
dc.contributor.authorid55655535300
dc.contributor.authorid9840981900
dc.contributor.authorid54885506700
dc.contributor.authorid54885506700
dc.contributor.authorid6507485003
dc.contributor.authorid55891568600
dc.contributor.citation55655535300|60018934|Mohieddin Jafari
dc.contributor.citation9840981900|60019580|Mehdi Sadeghi
dc.contributor.citation54885506700|60018934|Mehdi Mirzaie
dc.contributor.citation54885506700|60018934|Mehdi Mirzaie
dc.contributor.citation6507485003|60022927|Sayed Amir Marashi
dc.contributor.citation55891568600|60018934|Mostafa Rezaei-Tavirani
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60019580
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60022927
dc.contributor.affiliationid60018934


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