Cytotoxic activity of extracts and pure compounds of Bryonia aspera
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Cytotoxic activity of the root extracts and isolated compounds from Bryonia aspera Stev. ex Ledeb was evaluated against three cancer cell lines (MCF7, HepG2 and WEHI) and one normal cell line (MDBK) using MTT assay. Bryonia aspera is used for the treatment of cancer and various health problems by the local healers throughout the Golestan province in the northern part of Iran. Different fractions of Bryonia aspera showed antiproliferative activity against human breast cancer cell line MCF7 and normal cells MDBK and the activity was much more pronounced at the chloroform fraction. Therefore, compounds isolated from chloroform extract have been selected for further cytotoxicity evaluation. Among the compounds, neocucurbitacin C and cucurbitacins L showed promising cytotoxic activity.