Development and validation of a capillary zone electrophoretic method for the determination of atenolol in presence of its related substances in bulk and tablet dosage form
B. J. Clark
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The development of a capillary zone electrophoresis method for determination of the drug atenolol in the presence of its related substances in bulk and in a tablet dosage form is described. The method was fully validated in terms of repeatability (RSDs for migration time and peak area of atenolol at 0.05 mg ml -1 were 0.25% and 0.52%, n = 10, respectively), reproducibility (RSD of peak area 0.84%, n = 5), linearity at two ranges of atenolol concentration, limits of detection and quantitation, ruggedness and robustness. The method was applied to the determination of the drug in a commercial tablet preparation (recovery 99.4% m/m). The method proved to be fast and reliable for the quantitative analysis of atenolol in the presence of its related substances in bulk and pharmaceutical forms.