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dc.contributor.authorY. Fathollahi
dc.contributor.authorF. Motamedi
dc.contributor.authorS. Semnanian
dc.contributor.authorM. Zardoshti
dc.date.accessioned2017-09-18T09:23:31Z
dc.date.available2017-09-18T09:23:31Z
dc.date.issued1996-10-28
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/58888
dc.description.abstractThe effectiveness of θ pattern primed-bursts (PBs) on development of primed-burst (PB) potentiation was investigated in hippocampal CA1 of pentylenetetrazol-kindled rats. Experiments were carried out in the hippocampal slices from control and kindled rats at two post-kindling periods, i.e. 48-144 h (early phase) and 30-33 days (long-lasting phase). Field potentials (population excitatory post-synaptic potential, pEPSP) were recorded at stratum radiatum following stimulation of the stratum fibers. θ pattern primed-bursts were delivered to stratum radiatum and PB potentiation was assessed. The results showed that 48-144 h after kindling, PB potentiation in CA1 of kindled slices is significantly greater than control slices. In contrast, 30-33 days after kindling PB potentiation was not observed and the pEPSP slope was depressed after PBs delivery, which lasted at least 60 min. Our results suggest that shortly after kindling. PB potentiation can be more readily induced while one month later, it is more difficult to elicit. These findings may help to explain the behavioral deficits seen with the kindling model of epilepsy.
dc.sourceBrain Research
dc.subjectfield potential
dc.subjecthippocampal slice
dc.subjectpentylenetetrazol kindling
dc.subjectprimed-burst depression
dc.subjectprimed-burst potentiation
dc.titleRepeated administration of pentylenetetrazol alters susceptibility of rat hippocampus to primed-burst stimulation: Evidence from in vitro study on CA1 of hippocampal slices
dc.journal.volume738
dc.journal.issue1
dc.identifier.doi10.1016/0006-8993(96)00955-9
dc.journal.pages138-141
dc.contributor.authorid57189649887
dc.contributor.authorid55397033700
dc.contributor.authorid55929207800
dc.contributor.authorid6506682499
dc.contributor.citation57189649887|60032053|Y. Fathollahi
dc.contributor.citation55397033700|60018934|F. Motamedi
dc.contributor.citation55929207800|60022927|S. Semnanian
dc.contributor.citation6506682499|60007751|M. Zardoshti
dc.contributor.affiliationid60032053
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60022927
dc.contributor.affiliationid60007751


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