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dc.contributor.authorJavad Mirnajafi-Zadeh
dc.contributor.authorMohammad H. Pourgholami
dc.contributor.authorMohammad R. Palizvan
dc.contributor.authorMohammad Rostampour
dc.contributor.authorMansour Fallahi
dc.date.accessioned2017-09-18T09:22:39Z
dc.date.available2017-09-18T09:22:39Z
dc.date.issued1999-10-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/58786
dc.description.abstractPossible anticonvulsant effects of 2-chloroadenosine injected focally into the perirhinal cortex of amygdala kindled rats were investigated over a 2 h period. Animals were microinfused (1 μl) with 2-chloroadenosine (2-CLA; 5, 10, 15, 25 and 100 nM) or artificial cerebrospinal fluid applied through a cannula located in the perirhinal cortex. At the doses employed, 2-CLA significantly reduced afterdischarge duration and stage 5 seizure duration. The latency to stage 4 seizure was increased only at the highest dose of 2-CLA (100 nM), while even at this dose no significant change in seizure stage could be seen. The maximum effect of 2-CLA was obtained 30 min after microinfusion of the drug. Pre-treatment (intraperirhinal cortex) of animals with the nonselective adenosine antagonist, caffeine (50 μM; 1 μl), blocked the anticonvulsant activity of 2-CLA. These results suggest that adenosine receptors located in the perirhinal cortex may play an important role in the suppression of seizure activity elicited from the amygdala. Copyright (C) 1999 Elsevier Science B.V.
dc.sourceEpilepsy Research
dc.subject2-Chloroadenosine
dc.subjectAmygdala
dc.subjectCaffeine
dc.subjectPerirhinal cortex
dc.subjectSeizure
dc.titleAnticonvulsant action of 2-chloroadenosine injected focally into the perirhinal cortex in amygdaloid kindled rats
dc.journal.volume37
dc.journal.issue1
dc.identifier.doi10.1016/S0920-1211(99)00025-X
dc.journal.pages37-43
dc.contributor.authorid55938062100
dc.contributor.authorid6604061275
dc.contributor.authorid6508123323
dc.contributor.authorid7801555100
dc.contributor.authorid7005063034
dc.contributor.citation55938062100|60027708|Javad Mirnajafi-Zadeh
dc.contributor.citation6604061275|60018934|Mohammad H. Pourgholami
dc.contributor.citation6508123323|60027708|Mohammad R. Palizvan
dc.contributor.citation7801555100|60027708|Mohammad Rostampour
dc.contributor.citation7005063034|60018934|Mansour Fallahi
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60018934


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