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    Synthesis and anticonvulsant activity of 5-aryl-1,3,4-thiadiazole derivatives

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    Date
    2000-01-01
    Author
    A. Foroumadi
    S. A. Tabatabai
    G. Gitinezhad
    M. R. Zarrindast
    A. Shafiee
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    Abstract
    5-Aryl-1,3,4-thiadiazole derivatives were synthesized and tested for anticonvulsant activity using the pentylenetetrazole-induced lethal convulsion test. The results showed that 2-amino derivatives have anticonvulsant activity (LD50 > 500 mg kg -1 ) and this effect was not mediated through benzodiazepine receptors. The fluoro electron-withdrawing substituent on the phenyl ring did not potentiate the activity of the compounds.
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