Synthesis and anticonvulsant activity of 5-aryl-1,3,4-thiadiazole derivatives

Date
2000-01-01Author
A. Foroumadi
S. A. Tabatabai
G. Gitinezhad
M. R. Zarrindast
A. Shafiee
Metadata
Show full item recordAbstract
5-Aryl-1,3,4-thiadiazole derivatives were synthesized and tested for anticonvulsant activity using the pentylenetetrazole-induced lethal convulsion test. The results showed that 2-amino derivatives have anticonvulsant activity (LD50 > 500 mg kg -1 ) and this effect was not mediated through benzodiazepine receptors. The fluoro electron-withdrawing substituent on the phenyl ring did not potentiate the activity of the compounds.