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dc.contributor.authorMohammad Reza Zarrindast
dc.contributor.authorMohammad Reza Zarrindast
dc.contributor.authorMohammad Reza Zarrindast
dc.contributor.authorMohammad Reza Zarrindast
dc.contributor.authorMaryam Noorbakhshnia
dc.contributor.authorMaryam Noorbakhshnia
dc.contributor.authorMaryam Noorbakhshnia
dc.contributor.authorFreshteh Motamedi
dc.contributor.authorAli Haeri-Rohani
dc.contributor.authorAmeneh Rezayof
dc.date.accessioned2017-09-18T09:16:17Z
dc.date.available2017-09-18T09:16:17Z
dc.date.issued2006-01-01
dc.identifier.urihttp://dsp.sbmu.ac.ir/xmlui/handle/123456789/57930
dc.description.abstractIn the present study, the effects of intraperitoneal injections of GABA A receptor agonist and antagonist on memory formation and morphine state-dependent learning were investigated in rats. Pre-training administration of morphine (1-15 mg/kg) in a step-down passive avoidance task induced state-dependent learning with impaired memory retrieval on the test day. The impairment of memory was restored after the pre-test administration of the same dose of morphine. The pre-test administration of the GABA A receptor agonist, muscimol (0.01, 0.05 and 0.1 mg/kg), significantly decreased state-dependent retrieval induced by pre-test morphine (5 mg/kg). The state-dependency effect of morphine (1 mg/kg) was significantly potentiated by the pre-test administration of the GABA A receptor antagonist, bicuculline (0.125, 0.25 and 0.5 mg/kg). Furthermore, the pre-training injection of muscimol (0.01 mg/kg) impaired memory retrieval which was restored by pre-test morphine (1,3 and 5 mg/ kg) administration. However, the pre-training administration of bicuculline did not affect retention by itself. In addition, amnesia induced by pre-training morphine (5 mg/kg) was significantly reversed in rats which had received pre-test injections of muscimol (0.01, 0.05 and 0.1 mg/kg). Pre-test injections of bicuculline (0.125, 0.25 and 0.5 mg/kg) significantly decreased morphine-induced amnesia. It is concluded that the GABA A receptor mechanisms may be involved in the memory formation and it is postulated that these receptors may play an important role in morphine state-dependent learning. Copyright © 2006 S. Karger AG.
dc.sourcePharmacology
dc.subjectBicuculline
dc.subjectMorphine
dc.subjectMuscimol
dc.subjectPassive avoidance task
dc.subjectState-dependent learning
dc.titleEffect of the GABAergic system on memory formation and state-dependent learning induced by morphine in rats
dc.journal.volume76
dc.journal.issue2
dc.identifier.doi10.1159/000089934
dc.journal.pages93-100
dc.contributor.authorid7103216110
dc.contributor.authorid7103216110
dc.contributor.authorid7103216110
dc.contributor.authorid7103216110
dc.contributor.authorid11839131700
dc.contributor.authorid11839131700
dc.contributor.authorid11839131700
dc.contributor.authorid55397033700
dc.contributor.authorid6603206097
dc.contributor.authorid8885973300
dc.contributor.citation7103216110|60027708|Mohammad Reza Zarrindast
dc.contributor.citation7103216110|60027708|Mohammad Reza Zarrindast
dc.contributor.citation7103216110|60027708|Mohammad Reza Zarrindast
dc.contributor.citation7103216110|60027708|Mohammad Reza Zarrindast
dc.contributor.citation11839131700|60018934|Maryam Noorbakhshnia
dc.contributor.citation11839131700|60018934|Maryam Noorbakhshnia
dc.contributor.citation11839131700|60018934|Maryam Noorbakhshnia
dc.contributor.citation55397033700|60018934|Freshteh Motamedi
dc.contributor.citation6603206097|60027708|Ali Haeri-Rohani
dc.contributor.citation8885973300|60027708|Ameneh Rezayof
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60018934
dc.contributor.affiliationid60027708
dc.contributor.affiliationid60027708


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