Eneficial effects of broccoli sprouts and its bioactive compound sulforaphane in management of type 2 diabetes
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© 2016 by Nova Science Publishers, Inc. All rights reserved. Young broccoli sprouts are rich sources of many bioactive compounds, especially sulforaphane (SFN). Studies have shown that SFN has the potential to activate the antioxidant response signaling pathway, thereby inducing phase 2 enzymes. This will attenuate oxidative stress as well as inflammation. SFN, by activating the antioxidant response, also regulates lipid metabolism and glucose homeostasis. Anti-hypertensive, anti-cancer, cardio-protective, hypo-cholesterolemic capacity and antibactericidal properties against Helicobacter Pylori have also been reported for SFN. Clinical studies with high-SFN broccoli sprouts have shown increased total antioxidant capacity of plasma and a decrease in the following: the oxidative stress index, lipid peroxidation, serum triglycerides, oxidized-LDL/LDL-C ratio, serum insulin, insulin resistance, and serum high sensitive C reactive protein. Thus SFN has the potential to prevent diabetic vascular complications. Potential therapeutic efficacy of SFN and probably other bioactive components present in young broccoli sprouts make it as an excellent choice for supplementary treatment in Type 2 diabetes.