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Effect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat
(2013-01-01)
Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible fomotivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while ...
Glutamate receptors in nucleus accumbens can modulate canabinoid-induced antinociception in rat's basolateral amygdala
(2012-12-01)
Introduction: It has been shown that administration of WIN55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (BLA), dose-dependently increases the thermal latency to withdrawal in the tail-flick test ...
Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test
(2012-12-01)
Orexin (ORX) plays an important role in pain modulation. ORX receptors have been found in many brain structures and are known to be involved in pain processing. It is well-established that the acute and chronic forms of ...
Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats
(2012-07-23)
Objective: Echinophora platyloba DC is a widely used herbal medicine and food seasoning in Iran. It is claimed to exert antimicrobial, antifungal, and antispasmodic effects. Despite the prevalent use of this plant as a ...
Curcumin has neuroprotection effect on homocysteine rat model of Parkinson
(2012-06-01)
Parkinson's disease (PD) is a progressive neurological disorder which is emanated by dopaminergic death cell and depletion. Curcumin as a nontoxic matter has antioxidant, anti-inflammatory, and antiproliferative activities, ...
Study of in vitro and in vivo effect of docosahexaenoic acid on rat C6 glioma
(2009-12-01)
Docosahexaenoic acid (DHA) may have potential anti-carcinogenic effect. In the present study, effect of DHA on rat C6 glioma was tested. In vitro, cytotoxic effect of 50-400 μ M DHA on C6 cells was evaluated and compared ...
Vitamin E effects on intestinal damages in burned rats
(2013-01-01)
Background: Vitamin E is a fat-soluble agent protecting cells from free radicals damages. Previous studies have shown that oxidative stress plays an important role in mucosal intestinal damages in burn trauma. This study ...
The effect of nicotine administration on physical and psychological signs of withdrawal syndrome induced by single or frequent doses of morphine in rats
(2012-03-01)
Introduction: Morphine addiction and morphine withdrawal syndrome are the two main problems of today's human society. The present study has investigated the effects of nicotine on the strength of physical and psychological ...
Oral morphine consumption reduces lens development in rat embryos
(2012-03-01)
Introduction: Consumption of morphine, during pregnancy, in addition to inducing defects in the mother's nervous system function, caused defects or delays in the formation and evolution of embryonic visual system. In the ...
Involvement of dopamine receptors within the dorsal hippocampus in suppression of the formalin-induced orofacial pain
(2013-11-20)
It is widely established that the dopaminergic system has profound effects on pain modulation in different regions of the brain including the hippocampus, the salient area for brain functions. The orofacial region is one ...