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Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia
(2005-11-01)
There are some reports regarding the inhibitory effect of pain on tolerance development to analgesic effect of opioids. The present study was designed to investigate whether the chronic formalin induced pain is able to ...
Chronic forced swim stress inhibits ultra-low dose morphine-induced hyperalgesia in rats
(2007-11-01)
Ultra-low doses of morphine (UL-morphine) induce hyperalgesia, which is assumed to be mediated by stimulatory G proteins (Gαs) signaling pathway. Gαs pathway inhibition and chronic stress both attenuate development of ...
Alternative splicing in the synaptic protein interaction site of rat Ca<inf>v</inf>2.2 (α<inf>1B</inf>) calcium channels: Changes induced by chronic inflammatory pain
(2009-09-01)
Voltage-gated N-type Ca 2+ channels play a central role in regulation of neurotransmitter release. The II-III linker of N-type calcium channel α 1B subunit (exons 17-21 in rats) contains synaptic protein interaction ...
The effect of intra-locus coeruleus injection of 17β-estradiol on inflammatory pain modulation in male rat
(2010-12-01)
Estradiol is a neuroactive steroid found in several brain areas such as locus coeruleus (LC). It modulates nociception by binding to its receptors and also by allosteric interaction with other membrane-bound receptors like ...
Effect of chronic administration of morphine on the gene expression level of sodium-dependent vitamin C transporters in rat hippocampus and lumbar spinal cord
(2009-07-01)
Chronic morphine leads to dependence, tolerance, and neural apoptosis. Vitamin C inhibits the withdrawal syndrome in morphine dependent subjects and prevents apoptosis in experimental models. Sodiumdependent vitamin C ...
Dexamethasone mimics the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia and compensates for morphine induced changes in G proteins gene expression
(2006-08-09)
It is previously reported that the HPA axis plays role in the inhibitory effect of pain on tolerance development to analgesic effect of opioids. The present study was designed to investigate whether the chronic co-administration ...
Is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats mediated by GABA<inf>A</inf> receptors?
(2010-09-01)
Introduction: Estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (LC). Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other ...
Focal injection of Ethidium Bromide as a simple model to study cognitive deficit and its improvement
(2016-01-01)
Introduction: Memory and cognitive impairments are some of devastating outcomes of Multiple Sclerosis (MS) plaques in hippocampus, the gray matter part of the brain. The present study aimed to evaluate the intrahippocampal ...
Electromagnetic field stimulation potentiates endogenous myelin repair by recruiting subventricular neural stem cells in an experimental model of white matter demyelination
(2012-09-01)
Electromagnetic fields (EMFs) may affect the endogenous neural stem cells within the brain. The aim of this study was to assess the effects of EMFs on the process of toxin-induced demyelination and subsequent remyelination. ...
Castration attenuates myelin repair following lysolecithin induced demyelination in rat optic chiasm: An evaluation using visual evoked potential, marker genes expression and myelin staining
(2011-10-01)
Multiple sclerosis (MS) is a demyelinating disease that affects the central nervous system. MS is the most common neurological disorder in young adults with a greater incidence among females. Male gonadal hormones have a ...