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Germline mutations of RET proto-oncogene exon 2 in Iranian population with medullary thyroid carcinoma
(2016-03-01)
© 2016, Semnan University of Medical Sciences. All rights reserved. Introduction: Medullary thyroid carcinoma (MTC) accounts for 5-10% of all thyroid cancers andit is inherited in autosomal dominant pattern. Association ...
Diversity of mutations in the RET proto-oncogene and its oncogenic mechanism in medullary thyroid cancer
(2016-07-03)
© 2016 Informa UK Limited, trading as Taylor & Francis Group. Abstract: Thyroid cancer is the most common endocrine malignancy and accounts for nearly 1% of all of human cancer. Thyroid cancer has four main histological ...
Apolipoprotein e polymorphisms status in Iranian patients with multiple sclerosis
(2012-09-15)
Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system. Evidences linking apolipoprotein E (APOE) to myelin repair, neuronal plasticity, and cerebral inflammatory ...
Predominant RET germline mutations in exons 10, 11, and 16 in Iranian patients with hereditary Medullary thyroid carcinoma
(2011-12-01)
Medullary thyroid carcinoma occurs in both sporadic (75%) and hereditary (25%) forms. The missense mutations of RET proto-oncogene in MTC development have been well demonstrated. To investigate the spectrum of predominant ...
RET proto oncogene mutation detection and medullary thyroid carcinoma prevention
(2015-01-01)
the most aggressive forms of thyroid malignancy, accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are ...
Plasma levels of osteocalcin and retinol binding protein-4 in patients with medullary thyroid carcinoma
(2014-01-01)
Background: Thyroid carcinoma is the most frequent malignant tumor of the endocrine system in human body and accounts for nearly 1% of all cancers. Medullary thyroid carcinoma is the third frequent of thyroid cancer and ...
Skewed mutational spectrum of RET proto-oncogene Exon10 in Iranian patients with medullary thyroid carcinoma
(2015-07-29)
© 2015, International Society of Oncology and BioMarkers (ISOBM). Thyroid cancer is the most common endocrine malignant tumor. Medullary thyroid carcinoma (MTC) is an aggressive tumor arising from calcitonin-producing ...
Association between serum level of anti-TPO titer and polymorphisms G1193/C Exon 8 and C2145/T Exon 12 of thyroid peroxidase gene in an Iranian population
(2010-06-01)
Background: Autoimmune thyroid diseases (AITD) are common, with important epidemiological data, including family and twin studies, supporting a strong genetic background on the etiology of AITD. Objectives: The aim of this ...
Leptin: A correlated peptide to papillary thyroid carcinoma?
(2011-01-01)
Introduction: Leptin as an adipose-tissue-related peptide hormone contributes to the control of food intake, energy expenditure, and other activities such as cell proliferation. Therefore, association of leptin level with ...
Single nucleotide polymorphism of rs1800247 in promoter region of osteocalcin gene in patients with medullary thyroid carcinoma
(2014-01-01)
Background: Medullary thyroid carcinoma is a malignant tumor originated from parafollicular cells. Osteocalcin (OC) is the most non-collagenous protein in bone and its gene is located on chromosome 1 (1q25-q31). Important ...